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KMID : 0043319900130040306
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Archives of Pharmacal Research
1990 Volume.13 No. 4 p.306 ~ p.309
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Synthesis and Biological Effects of Some 5-Heterocyclicmethyl-2’’-deoxyuridines
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Kwak IY
Ryu EK
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Abstract
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The synthesis of 5-heterocyclicmethyl-2’’-deoxyuridines (4a-f) has been accomplished by displacement reaction of 5-(bromomethyl)-3’’,5’’-di-O-acetyl-2’’-deoxyuridine with heterocyclic compounds, followed by removal of acetyl protecting group with methanolic ammonia. The compounds synthesized were evaluated the inhibitory effects on L1210 cell proliferation and antiviral activities against Herpes simplex virus type 1 (HSV-1). None of the compounds exhibited sufficient biological activities.
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KEYWORD
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